Juan Rosai (August 20, 1940 – July 7, 2020) was an Italian-born American physician who contributed to clinical research and education in the specialty of surgical pathology. He was the principal author and editor of a major textbook in that field, and he characterized novel medical conditions such as Rosai-Dorfman disease and the desmoplastic small round cell tumor. Rosai is also well-known because of his role as teacher, mentor and consultant to many American and international surgical pathologists.
Early life and education
Juan Rosai was born in Poppi, a little town near Florence, province of Arezzo, in the region of Tuscany, Italy. When he was eight years old, his parents emigrated to Buenos Aires, Argentina because of the economic problems in Italy after World War II. His original first name was Giovanni Rosai, but after his family settled in Argentina his first name was changed to the equivalent Spanish name Juan. At the age of 15, Rosai enrolled in the Faculty of Medicine at the University of Buenos Aires. During his third year of medical school, he met Eduardo Lascano, a pathologist who influenced young Rosai's interest in that discipline following the teachings of Pío del Río Hortega, Lascano mentor. Rosai earned the M.D. degree at the age of 21, and then he did the residency training in Anatomic Pathology at the same university, under the direction of Lascano. While serving subsequently as a house officer in pathology at the Regional Hospital of Mar del Plata, Rosai was introduced to Lauren Ackerman at a medical conference in Argentina. Ackerman invited Rosai to train with him in St. Louis, Missouri in the United States.
Career in the United States
Rosai completed his residency and fellowship in anatomic pathology at Washington University School of Medicine and Barnes Hospital under Lauren Ackerman's mentoring. Subsequently, he remained on the faculty of Washington University until 1974 when, at the age of 34, Rosai was appointed Professor & Director of Anatomic Pathology at the University of Minnesota. He left there in 1985 for an identical position at Yale University School of Medicine in New Haven, Connecticut, where he stayed until 1991. From 1991 to 1999, Rosai was the James Ewing Alumni Professor and Chairman of Pathology at Memorial Sloan-Kettering Cancer Center in New York City.
Work in Italy and the United States
Juan Rosai maintained ties to Italy, his home country, throughout his life. In 1982–1983 he spent a sabbatical year at the University of Florence and the University of Bologna. In 2000 Rosai moved permanently back to Italy as Chairman of the Department of Anatomic Pathology at the Istituto Nazionale dei Tumori (National Cancer Institute) in Milan, Italy. Later, in 2005, he created the Center for Oncologic Pathology Consultations, located at the Centro Diagnostico Italiano in Milan, where he continued his consultation and educational activities focusing on oncological surgical pathology.
During his work in Italy, Rosai maintained academic connections to the United States as adjunct professor of pathology at the Weill Cornell Medical College of Cornell University, visiting professor of pathology at Harvard University and Massachusetts General Hospital, and senior consulting pathologist at Genzyme Genetics (LabCorp). He also was consultant pathologist for the Department of Pathology of the University of Utah and ARUP Laboratories, providing surgical pathology consultation through telepathology while still working in Milan.
Illness and death
Rosai developed Parkinson's disease in his late 60s. It was well-controlled for many years, but he died from complications of the condition in July 2020 at the age of 79.
Scientific publications
Rosai was an author of more than 400 scientific peer-reviewed papers on topics in pathology, including the seminal descriptions of entities such as sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease), desmoplastic small round cell tumor, spindle-cell epithelial tumor with thymus-like differentiation of the thyroid, and sclerosing angiomatoid nodular transformation of the spleen. He was Editor-in-Chief of the International Journal of Surgical Pathology until 2014 and served as a member of the editorial boards of several other pathology journals. Rosai was also Editor-in-Chief of the 3rd Series of the Atlas of Tumor Pathology of the Armed Forces Institute of Pathology (AFIP), and author of AFIP fascicles on Tumors of the Thymus and Tumors of the Thyroid Gland, and a book on the history of American surgical pathology called Guiding the Surgeon's Hand. He has also edited or co-edited 13 other books.