The De La Brooke Tobacco Barn is a historic tobacco barn in rural northern St. Mary's County, Maryland. It is located in a clearing on the north side of Delabrooke Road, about east of Maryland Route 6, north of Oraville. The barn measures 36 feet by 42 feet 6 inches (), and is oriented with its gable ends southeast and northwest. Built about 1815 (or possibly somewhat earlier), it is a well-preserved example of a period tobacco drying barn, which also utilizes a unique internal system of tier poles inside. It is part of the Cremona Farm estate.
The barn was listed on the National Register of Historic Places in 2015.