In Ohio's 6th district, incumbent William Creighton Jr. resigned before December 19, 1828 when he was given a recess appointment to be a United States District Judge. He was also nominated for the judgeship, but that appointment was not approved by the U.S. Senate by February 1829. Creighton was already elected to the next term and was reseated in his old position when the next Congress began in March 1829.
Francis S. Muhlenberg was elected December 2, 1828 only to finish that short term.