The 2010–11 season was ACF Fiorentina's 85th season in Italian football and their 73rd season in the first-tier, Serie A. This was also the sixth consecutive season for the club in the top-level division of the Italian football league system.
After five seasons at the helm of the Tuscan club, Cesare Prandelli was succeeded by Siniša Mihajlović, with the former taking the role as head coach of the Italy national team. For Fiorentina, this was also the first season from the last three that Fiorentina did not compete in a European competition, after finishing 11th the previous season.