The following have been listed as variant names of the Potomac River throughout its history by the Geographic Names Information System. The Board on Geographic Names officially decided upon Potomac as its spelling in 1931.

Potomac River

Cheneoow-quoquey

Co-hon-go-roo-ta River

Co-hon-go-ru-ta River

Cohongaroota River

Cohongoluta River

Cohongoronta River

Cohongoronto River

Cohongoroota River

Cohongorooto River

Cohongoruton River

Elisabeth River

Elizabeth River

Kahongoronton River

Maryland River

Pataromerke River

Patawmack River

Patawomeck River

Patawomecke River

Patawomek River

Patawomeke River

Patomack River

Patomacke River

Patomak River

Patomake River

Patomeck River

Patomecke River

Patomeke River

Patoumak River

Patowmack River

Patowmacke River

Patowmec River

Patowmeck Flu

Patowmeck River

Patowomeck River

Patowomek River

Pawtomack River

Pokomoach River

Potamack River

Potamak River

Potawmack River

Potomack River

Potomacke River

Potomak River

Potomeack River

Potomock River

Potomoke River

Potomuck River

Potomucke River

Potowmac River

Potowmack River

Potowmak River

Potowomek River

Pottomock River

Powtowmac River

Powtowmack River

Quattaro

Qui-o-riough River

Quiriough River

River Potowmack

Saint Gregories River

Saint Gregory River

San Pedro River

Satawomeck

Turkey Bussard River

Wappacomma River

North Branch Potomac River

Cohongoronton

Kahun-gulta

North Branch

North Branch Patamac River

North Fork Potomac River

South Branch Potomac River

South Branch of Potowmac River

South Branch of the Potowmack River

South Fork Potomac River

Wapacomo River

Wapocomo River

Wappacoma River

Wappatomaka River

Wappatomica

Potomac River

Alternative place names

List of variant names of the Potomac River