This is a complete list of estrogens and formulations that are approved by the and available in the United States. Estrogens are used as hormonal contraceptives, in hormone replacement therapy, and in the treatment of gynecological disorders.
Estrogen-only
Oral/sublingual pills
Conjugated estrogens (Premarin) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg, 0.625 mg, 1.25 mg, 2.5 mg Estradiol (Estradiol, Gynodiol, Innofem) – 0.5 mg, 1 mg, 2 mg Estradiol acetate (Femtrace) – 0.45 mg, 0.9 mg, 1.8 mg Synthetic conjugated estrogens (Cenestin, Enjuvia) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg
Atypical (dual estrogen and nitrogen mustard alkylating antineoplastic):
Estramustine phosphate sodium (Emcyt) – 140 mg
Oral estradiol valerate (except in combination with dienogest as an oral contraceptive) is not available in the U.S. and is used primarily in Europe.
Transdermal forms
Patches
Estradiol (Alora, Climara, Esclim, Estraderm, Estradiol, Fempatch, Menostar, Minivelle, Vivelle, Vivelle-Dot) – 14 μg/24 hours, 25 μg/24 hours, 37.5 μg/24 hours, 50 μg/24 hours, 60 μg/24 hours, 75 μg/24 hours, 100 μg/24 hours
Gels
Estradiol (Divigel, Elestrin, Estrogel) – 0.06% (0.87 g/activation, 1.25 g/activation), 0.1% (0.25 g/packet, 0.5 g/packet, 1 g/packet)
Sprays
Estradiol (Evamist) – 1.53 mg/spray
Emulsions
Estradiol hemihydrate (Estrasorb) – 0.25%
Vaginal forms
Tablets
Estradiol (Estradiol, Vagifem) – 10 μg (25 μg discontinued)
Creams
Conjugated estrogens (Premarin) – 0.625 mg/g (0.0625%) Estradiol (Estrace) – 0.01% Synthetic conjugated estrogens (Synthetic Conjugated Estrogens A) – 0.625 mg/g (0.0625%)
Inserts
Estradiol (Imvexxy) – 4 μg, 10 μg
Rings
Estradiol (Estring) – 7.5 μg/24 hours
Estradiol acetate (Femring) – 50 μg/24 hours, 100 μg/24 hours
Intramuscular injection
Conjugated estrogens (Premarin) – 25 mg/vial
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL
Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Combined with progestins
For contraception
⇾ See here instead.
For menopausal symptoms
Oral pills
Conjugated estrogens and medroxyprogesterone acetate (Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro, Prempro (Premarin, Cycrin), Prempro/Premphase) – 0.3 mg / 1.5 mg; 0.45 mg / 1.5 mg; 0.625 mg / 2.5 mg; 0.625 mg / 5 mg Estradiol and drospirenone (Angeliq) – 0.5 mg / 0.25 mg; 1 mg / 0.5 mg Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg Estradiol and progesterone (Bijuva) – 0.5 mg / 100 mg; 1 mg / 100 mg
Transdermal patches
Estradiol and levonorgestrel (Climara Pro) – 45 μg/24 hours / 15 μg/24 hours
Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours