Szapiro is a Polish Jewish surname, a variant of Shapiro. Notable people with this surname include:
Anna Szapiro, mother of Georges Charpak
Deborah Szapiro, film producer
Jakub Szapiro, The King of Warsaw (TV series) main character
Gedali Szapiro (Grzegorz Szapiro, Gedalia Shapira, 1929–1972), Polish–Israeli chess master Hanna Sawicka (Hanna Krystyna Szapiro 1917–1943), Polish communist Henoch Szapiro (Henryk Szaro, 1900–1942), Polish screenwriter and film director Klonimus Kalmish Szapiro (1889–1943), Grand Rabbi of Piaseczno, Poland Marek Szapiro (1884-1942), artist Salomea Szapiro, mother of Stefan Kisielewski Salomon Szapiro (1882–1944), Polish chess master Shayne-Feygl Szapiro (Dina Blond, 1887-1985), member of the Jewish Labour Bund in Poland and a prolific Yiddish translator Willy Schapiro (also Szapiro or Schapira, 1910–1944), Polish Jew soldier