St. Catherine Creek National Wildlife Refuge was established in January 1990 to preserve, improve and create habitat for waterfowl. Intensive management programs on the refuge provide excellent winter habitat and resting areas for waterfowl in the Lower Mississippi River Valley.
Encompassing nearly , with a potential size of , the refuge is located in Adams County in southwest Mississippi. The headquarters lies south of Natchez, Mississippi. Natchez is the oldest settlement on the Mississippi River and is world-renowned for its beautiful antebellum homes. The western refuge boundary is formed by the Mississippi River. The eastern boundary meanders along the loessal bluffs and the southern boundary borders the Homochitto River.