Milanlu Rural District () is in the Central District of Esfarayen County, North Khorasan province, Iran.
At the National Census of 2006, its population was 3,936 in 891 households. There were 3,293 inhabitants in 911 households at the following census of 2011. At the most recent census of 2016, the population of the rural district was 3,904 in 1,151 households. The largest of its 46 villages was Ordaghan, with 767 people. Among the rural district's other villages are: Anushirvan, Barastu, Bidvaz, Dar Parchin-e a Olya, Dar Parchin-e Sofla, Ganjdan, Hasanaba, Hesar-e Kazimabad, Jan Ahmadi, Kalateh-ye Habib, Kalateh-ye Pialeh, Karimabad-e Olya, and Parkanlu.