Qaleh-ye Khvajeh Rural District () is in the Central District of Andika County, Khuzestan province, Iran.
At the National Census of 2006, its population (as a part of the former Andika District of Masjed Soleyman County) was 13,094 in 2,218 households. There were 11,654 inhabitants in 2,418 households at the following census of 2011, by which time the district had been separated from the county in the establishment of the new Andika County. At the most recent census of 2016, the population of the rural district was 11,119 in 2,778 households. The largest of its 133 villages was Taherabad, with 652 people.