The Sixty Years' War (; 1754–1815) was a military struggle for control of the North American Great Lakes region, including Lake Champlain and Lake George, encompassing a number of wars over multiple generations. The conflicts involved the British Empire, the French colonial empire, the United States, the Spanish Empire, and the Indigenous peoples of the Americas. The term Sixty Years' War is used by academic historians to provide a framework for viewing this era as a whole, rather than as isolated events.

French and Indian War (1754–1763)

Sixty Years' War

Canadians view this war as the American theater of the Seven Years' War, whereas Americans view it as an isolated American conflict with no bearing on European conflicts. Some scholars interpret this war as part of a larger struggle between the Kingdoms of Great Britain and France; most historians view it as a conflict between the colonies of British America and those of New France, each supported by various Indian tribes with some assistance from the "mother country". Both sides sought control of the Ohio Country and Great Lakes region, known in New France as the "upper country" (the pays d'en haut). Indians of the pays d'en haut had longstanding trade relations with the French and generally fought alongside the French. The Iroquois Confederacy attempted to remain neutral in the conflict, except for the Mohawks who fought as British allies. British conquest of New France marked the end of French colonial power in the region and the establishment of British rule in Canada.

Sixty Years' War

Pontiac's War (1763–1765)

Sixty Years' War

American Indian allies of the defeated French launched a war against the British due to dissatisfaction with their handling of tribal diplomacy. Pontiac found allies willing to attack British forts from Detroit in modern day Michigan, to Pennsylvania and New York, and even down the Mississippi. British forces eventually forced small groups of Native Americans to surrender, breaking the expansive alliance and leading to a negotiated truce. The murder of Pontiac in 1769 led to war between Native American nations.

Lord Dunmore's War (1774)

The expansion of colonial Virginia into the Ohio Country sparked a war with Ohio Indians, primarily Shawnees and Mingos, forcing them to cede their hunting ground south of the Ohio River (Kentucky) to Virginia. This also began a period sometimes referred to as the Twenty Years War, in which the Shawnee struggled against incursions into their territory.

Western theater of the American Revolutionary War (1775–1783)

The Royal Proclamation of 1763 prohibited American colonists from settling the lands acquired from France at the conclusion of the French and Indian War, but this caused resentment among the colonists and is often cited as one of the causes of the American Revolutionary War (1775-1783). The war spilled onto the frontier, with British military commanders in Canada working with North American Indian allies to provide a strategic diversion from the primary battles in the east coastal colonies. Many conflicts in this western theater would harden the animosity between the native tribal nations and the new United States.

At the conclusion of the war, Great Britain ceded to the new United States the Old Northwest, home of many of Britain's Indian allies, and all of the lands south to the Gulf of Mexico. The Treaty of Paris (1783) granted the United States jurisdiction to the Mississippi River without consulting the Native nations who lived there.

Northwest Indian War (1785–1795)

Following the 1783 peace treaty with Great Britain, a nascent United States sought expansion into the Ohio Territory. A large confederacy of Native American nations resisted settlement and sought to establish the Ohio River as the boundary between themselves and the United States. After years of minor skirmishes between militias and Native Americans, the United States launched a series of punitive campaigns deep into the Great Lakes region. The confederacy won overwhelming victories in 1790 and 1791, and gained support from Great Britain. The United States was forced to rebuild the Army and finally defeated the confederate forces at the 1794 Battle of Fallen Timbers. The confederation fractured, and the war officially ended with the Treaty of Greenville, which granted to the United States control over most of the modern state of contested Ohio.