Mozambique competed at the 2012 Summer Olympics in London, from 27 July to 12 August 2012. This was the nation's ninth consecutive appearance at the Olympics. In the weeks before the Games, Mozambique athletes trained at Comberton Village College in Cambridge.
The Mozambique National Olympic Committee () sent the nation's largest delegation to the Games since the 1992 Summer Olympics in Barcelona. A total of 6 athletes, 4 men and 2 women, competed in athletics, boxing, judo, and swimming. Track hurdler Kurt Couto, who was considered Mozambique's best medal prospect at the Olympics, reprised his role as the nation's flag bearer for the third consecutive time. Mozambique, however, again failed to win a single Olympic medal. They have not won an Olympic medal since the 2000 Summer Olympics in Sydney, where middle-distance runner Maria Mutola became the nation's first ever Olympic champion.
Athletics
Mozambique athletes have so far achieved qualifying standards in the following athletics events (up to a maximum of 3 athletes in each event at the 'A' Standard, and 1 at the 'B' Standard):
Men
Women
Boxing
Mozambique has so far qualified boxers for the following events
Men
Judo
Mozambique has qualified 1 judoka.
Swimming
Mozambique has gained two "Universality places" from the FINA.