The 2021–22 Croatian Women's First Football League (Croatian: Prva hrvatska nogometna liga za žene) was the 31st season of Croatian Women's First Football League, the national championship for women's association football teams in Croatia, since its establishment in 1992. The season started on 5 September 2021 and ended on 29 May 2022.
The league was contested by eight teams. First stage was played in a double round robin format, with each team playing every other team two times over 14 rounds. In a second stage teams were divided in two groups according to the table standings. ŽNK Osijek were the defending champions, having won their 23rd title in 2020–21.
Teams
The following is a complete list of teams who have secured a place in the 2021–22 Croatian Women's First Football League.
Regular season
League table
Results
Play-offs
Championship play-offs
League table
Results
Relegation play-offs
League table
Results
Relegation play-off
At the end of the season, seventh placed Donat will contest a two-legged relegation play-off tie against the losing team of promotion play-off tie between Hajduk Split and Viktorija.
First leg
Second leg
Donat won 9–0 on aggregate.
Top scorers
Updated to matches played on 29 May 2022.