If such results can be ascribed to _Parthenium_ and its alkaloid _Parthenina_, I think it would be unjustifiable to set them aside. An early proving of the plant will not only enhance our therapeutic resources, but prevent the non-scrupulous from employing it empirically.
Proving of _Parthenium hysterophorus_, Dr. B. H. B. Sleght.
February 12th.--Until a few days ago had a slight continuous toothache due to a cavity in last molar of lower jaw; cavity recently filled. General health has been excellent for some time.
7:40 A.M. Took 5 drops of tincture. At once have a full feeling in head, especially vertex, pressing from within.
7:50. Took 10 drops. Ringing and fulness continue and become worse.
7:58. Upper teeth feel "on edge," with slight prickling pains in sockets, which slowly grow more severe.
8:00. Breakfast; above symptoms continue, but grow less severe.
8:10. Loud rumbling in bowels; irrepressible eructations, tasteless.
8:20. 20 drops. A "shivery" feeling runs over limbs and back as this is taken. Singing in ears had ceased but begins again, as does the rumbling.
8:40. "Goneness" in epigastrium, singing ceases; some fulness in head remains.
8:45. Same feeling in teeth as above; singing in ears; head thick, heavy.
8:50. Sharp, aching twinges in upper molars; some sharp pains in ears. Pulse 72.
9:15. Stitching pain in left temple, of short duration. Upper incisors tender at sockets when biting.
9:25. Sudden pain in upper teeth with lachrymation, < pressing jaws together.
9:55. Aching pain at left supra-orbital foramen. On going into open air no symptoms but taste of drug and fulness of head. A tooth filled yesterday aches slightly, same as before filling.
11:15. 60 drops. Renewed fulness of head. Pulse 76.
11:30. Goneness in epigastrium; vertigo while sitting, with heat of face and blurred vision. Aching at supra-orbital foramen (left), extending to root of nose and becoming more severe there, > eyes closed. Feel dull, stupid. Goneness comes and goes; hunger.
11:45. Aching at lower edge of right ear spreads over side of face; ear feels plugged up. Am drowsy, eyes "heavy;" goneness and unusual craving for food.
11:50. Prickling in skin of back of wrists and hands. A twinge of pain at right infraorbital foramen, gradually increases; cannot fix attention on what I am reading. Hard, painful lump in epigastrium; better after eructations tasting of drug. Slight nausea with some relief.