MacPhail is a surname. People with the surname include:
Agnes Macphail (1890–1954), Canadian feminist and first woman to be elected to the Canadian House of Commons. Andrew Macphail (1864–1938), Canadian physician, author, professor of medicine and soldier. Andy MacPhail (born 1953), president of baseball operations for the Baltimore Orioles and son of the former American League president Lee MacPhail and grandson of Larry MacPhail. Angus MacPhail (1903–1962), English screenwriter known for his work with Alfred Hitchcock; credited with the creation of the term "MacGuffin" John MacPhail (born 1955), former Scottish footballer Joy MacPhail, former Canadian New Democratic Party of British Columbia politician Larry MacPhail (1890–1975), American executive and innovator in Major League Baseball Lee MacPhail (born 1917), former administrator in Major League Baseball Malcolm MacPhail, World War One books Mark MacPhail (died 1989), police officer and murder victim Robert Lloyd George MacPhail (1920–1995), Canadian politician and the 36th Lieutenant Governor of Prince Edward Island; Member of the Order of Canada Catherine Macphail (born 1964), Scottish-born author William S. MacPhail (fl. 1900s), namesake of the MacPhail Center for Music in Minneapolis, Minnesota Dan Macphail, fictitious engineer of the Vital Spark