The 1944 United States Senate election in Oklahoma took place on November 7, 1944. Incumbent Democratic Senator Elmer Thomas ran for re-election to a fourth term. Thomas once again faced a stiff challenge in the Democratic primary, this time from Congressman Wesley E. Disney and Lieutenant Governor James E. Berry. As was the case in 1938, Thomas won renomination only with a narrow plurality. In the general election, he faced former State Senator William J. Otjen, the 1942 Republican nominee for Governor. Though Thomas's performance was much reduced compared to six years prior, he still defeated Otjen by a wide margin.
Democratic primary
Candidates
Elmer Thomas, incumbent U.S. Senator
Wesley E. Disney, U.S. Congressman from Oklahoma's 1st congressional district
James E. Berry, Lieutenant Governor of Oklahoma
Elmer Fraker
Fletcher S. Riley
A. F. Shaw
Dan Nelson
Charles West
Lily Allen Lasley
Lattie Hughes
Results
Republican primary
Candidates
William J. Otjen, former State Senator, 1942 Republican nominee for Governor
Pat W. Murphy, Cushing clergyman
Harry O. Glasser, former State Senator, 1938 Republican nominee for the U.S. Senate O. O. Owens Frank A. Anderson Fred E. Pickard John M. Claypool S. M. Stauffer Sim L. Liles