I have experimented on upwards of sixty animals--dogs, cats, mice, rats, guinea pigs, rabbits, frogs, and toads. After the ingestion of the poison the symptoms appear from two minutes to thirty, more generally about five or six. The symptoms in their order are--a desire to be quite still; hurried breathing; slavering at the mouth when given at the mouth; twitching of the ears; trembling of the muscles; inability to walk; convulsion of all the muscles of the body; the jaws generally being firmly closed during convulsions; these convulsions followed by a total want of power in the muscles, which, in the last attacks, were thrown into violent spasms with a galvanic-like shock running through them. Spasms come on if the animal is either touched or attempts to move. These spasms occur at various periods. The animals die at various periods up to three and a half hours. In every case before death the rigidity ceases, and the muscles are quite soft and powerless. The longest intervals between the violent convulsions in the animals to which strychnia has been administered has been about half an hour, but that is not common. After death the hearts of the animals have been invariably full on the right side, very generally the left ventricle firmly contracted, and the blood usually dark and often fluid. There is no particular appearance attached to the spine. I have attended to the evidence as to the symptoms of Mr. Cook on the Monday and Tuesday nights.
By LORD CAMPBELL--What do you assume the symptoms to have been on the Saturday night?--A state of great excitement in a less severe form; that Mr. Cook described himself to have been very ill.
Examination resumed--What else?--In a condition that he considered himself mad for two minutes, caused, he stated, through some noise in the street.
Now, adverting to the symptoms described on these three occasions here in the Court, is it your opinion that they could have been produced by the poison of strychnia?--They did not resemble what I have seen to follow it. He had more power of voluntary motion--sitting up in bed, moving his hands about, freely swallowing, and asking to be rubbed and moved, and a greater length of time occurred from the taking of the pills supposed to contain strychnia and the occurrence of the symptoms, much greater than any period that has occurred in my experience.