The supreme pontificate, perhaps, never fell upon a soul more disturbed and afflicted than that of this monk, who saw himself thus condemned to exchange the peace of the cloister for the cares of the government of the Church, and the special defence of the interests of Italy. Not only then, but during all his life, he did not cease to lament his fate. "I have lost," he wrote to the sister of the emperor, "the profound joys of repose. I seem to have been elevated in external things, but in spiritual I have fallen." To the patrician Narses: "I am so overcome with melancholy, that I can scarcely speak. I cannot cease considering the height of tranquillity from which I have fallen, and the height of embarrassment I have ascended." To his friend Leander: "I am so beaten by the waves of this world, that I despair of being able to guide to port this rotten old vessel with which God has charged me. I weep when I recall the peaceful shore which I have left, and sigh in perceiving afar what I now cannot attain."
The poor monk who showed so much despair when he was thrown into the political whirlpool by the unanimous voice of the Romans, could yet perceive with a bold and clear glance the dangers of the situation, and adopt a line of conduct most suitable to the emergency of the times. First of all he concerned himself with the Lombards. After nine years' exertion, in overcoming Byzantine repugnance to acknowledge any right whatever on the side of the Lombards, he concluded a peace between the two powers, which made Italy, exhausted by thirty years of war and brigandage, thrill with joy. It was of short duration; but when hostilities recommenced, he entered into direct negociations with king Agilulf, and obtained from that prince a special truce for Rome and its surrounding territory. He had besides found a powerful advocate with the Lombard king in the person of the illustrious queen Theodelinda. This princess, a Bavarian and Catholic by birth, had gained the hearts of the Lombards. The queen was always the faithful friend of the pope; she served as a medium of communication between him and her husband. Gregory, from the very beginning of his pontificate, had exhorted the Italian bishops to make special exertions for the conversion of these formidable heretics.