The 2022 McNeese State Cowboys football team represented McNeese State University as a member of the Southland Conference during the 2022 NCAA Division I FCS football season. Led by first-year head coach Gary Goff, the Cowboys compiled an overall record of 4–7 with a mark of 2–4 in conference play, placing sixth in the Southland. McNeese State played home games at Cowboy Stadium in Lake Charles, Louisiana.
Preseason
Preseason poll
The Southland Conference released its preseason poll on July 20, 2022. The Cowboys were picked to finish fourth in the conference.