Guide Seamount is a seamount in the eastern Pacific Ocean, about 16.6±0.5 million years old. It is similar in shape and orientation to the nearby Davidson, Pioneer, Rodriguez, and Gumdrop seamounts. It is named for the United States Coast and Geodetic Survey survey ship USC&GS Guide.
Guide Seamount is constructed of four nearly parallel volcanic ridges, separated by sediment-filled throughs. These are aligned parallel to magnetic anomalies in the underlying oceanic crust. It is very similar in shape and structure to the nearby Davidson Seamount, except that it is smaller, at approximately by . It rises about above the seafloor and sits at depth of .
The lavas from Guide are mostly alkalic basalt, hawaiite, mugearite with some pyroclastic flows near the top of the summit.