The 1500's were a time of religious bickerings and of religious wars, of Henry the VIII's break with Rome, of the German wars following the death of Martin Luther, and the Inquisition in Spain. In the early part of the century there was working at Lyons, which was then second only to Paris as a printing center in France, a young scholar and printer named Etienne Dolet.[24] There is a story that he was the illegitimate son of Francis I, but at any rate he came of a wealthy family, having been to Venice as secretary to the French Ambassador and to Toulouse to study law. By the time he was twenty-seven he had published a Latin Dictionary which was "one of the most important contributions to classical scholarship in the century" and was given a license by Francis I providing that Dolet might print for ten years any books written or supervised by him. His great range of taste and interests may be judged by the fact that he printed the New Testament in Latin and Rabelais in French.
He had met Rabelais when he first went to Lyons to work under Sebastian Gryphius as proof-reader, and there gained his practical knowledge of printing under the foreman, Jean de Tournes. E. D. Christie, Dolet's biographer, says that Dolet, arriving in Lyons with a fever, may have been taken directly to Rabelais, who was at that time practising medicine, with the position of Physician to the Great Hospital. Christie also thinks it possible that Dolet may have seen Rabelais perform a dissection on a man's body ten years before Vesalius. Everything Dolet did shows him to have been a man with lively fearless intellect and no talent for playing safe and keeping out of trouble. He spent several terms in jail for lack of orthodoxy on religious questions, was pardoned by Francis I for killing a man, and was denounced by Rabelais for printing an unexpurgated edition of _Pantagruel_ after Rabelais had fixed it up to suit the Sorbonne.
At Lyons in the months of April and May, 1539, there occurred the first large organized printers' strike. It was no wonder, for Updike says that it was not unusual for the printers' day to begin at two in the morning and last until eight or nine at night. The workmen said that the masters did not supply sufficient food, that wages had been reduced, that there were too many compulsory holidays. The Seneschal of Lyons was empowered to meet a committee of journeymen and one of masters; at this conference rules were drawn up. But the trouble spread to Paris, and as a result of arbitration there, the working day was set from five in the morning till eight at night. Then there was a flare-up at Lyons again because the master printers threatened to move away; this was some years in settlement.