A cloud of the noblest champions and witnesses of God had already departed to that place where we rest after the battle, and where the confessor receives the reward of grace. Melanchthon had long before this desired to lay aside his arms, and to celebrate a Sabbath, in which he might sing the new song to him that sitteth upon the throne, with his friends Luther, Cruciger, Veit Dietrich, Sturm, Bucer, Bugenhagen, and all the company of the saints made perfect. He had also expressed this longing towards the eternal home in many of his letters. The most ancient account, that of the University, says in regard to this: "When he had now become worn out, and weary of this life, he prepared himself for death for several years; even as he wrote concerning himself, that he was tired of this life, and was therefore directing his thoughts to another world, and towards his beloved Lord Jesus Christ. That he had done as much as he could in this life, and would leave the rest with God. He comforted himself with the reflection that he had always meant well, and his conscience did not accuse him on this account. And with this clear conscience, he trusted to go "into the presence of his Lord Jesus, with God's help, no matter what an ungrateful world might say about it." Whenever his opponents attacked him at this time, he would say: "Let them write until they are satisfied, and do whatever they please, I shall not trouble them much longer. But I, with God's help, will continue to teach diligently, and present a simple exposition of truth to the young, as long as I live, and will pray God to grant me a joyful departure." To this mental weariness, bodily infirmities were added. He began to experience great difficulty in writing letters, which he had done with much ease formerly; and his eyes, too, grew weaker.
On the 30th of March, 1560, he departed for Leipzig, in order to examine the stipendiaries of the Elector. After he had finished his labors, he left Leipzig on the 4th of April. His journey affected him very unfavorably, for the air was inclement and cold, and they were riding against a cutting north wind. He said, even while in the carriage, "that he had not felt the coldness so much during the whole winter, as he did now." He was able to sleep very little during the night from the 7th to the 8th of April; towards morning he was affected with fever, accompanied by a cough and shortness of breath, and his eyes appeared so sunken, that his friends were terrified. But notwithstanding all this, he roused himself from his couch to attend to his duties, but found himself so much exhausted by his efforts, that he was repeatedly obliged to totter to his couch, to refresh himself. During this day, he yet wrote a short letter to Moller, and apologized for its brevity on account of the severe pain he was suffering. His son-in-law, Doctor Peucer, thought that the affection of the stone, with which his father-in-law had suffered severely before, was again making its appearance, and had a bath and warm poultices prepared for him.