This is a list of bestselling novels in the United States in the 2000s (decade), as determined by Publishers Weekly. The list features the most popular novels of each year from 2000 through 2009.

The books in the Harry Potter series are excluded "because of the way AAP [Assoc of American Publishers] measures industry sales. The organization takes actual sales from 81 reporting companies (including Potter publisher Scholastic) and then uses Census Bureau data to extrapolate sales for the entire industry. In the past, the inclusion of Potter novels has distorted growth (and, in non-Potter years, the decline) of the children's category."

Publishers Weekly list of bestselling novels in the United States in the 2000s

2000

The Brethren by John Grisham

The Mark: The Beast Rules the World by Jerry B. Jenkins and Tim LaHaye

The Bear and the Dragon by Tom Clancy

The Indwelling: The Beast Takes Possession by Jerry B. Jenkins and Tim LaHaye

The Last Precinct by Patricia Cornwell

Journey by Danielle Steel

The Rescue by Nicholas Sparks

Roses Are Red by James Patterson

Cradle and All by James Patterson

The House on Hope Street by Danielle Steel

2001

Desecration by Jerry B. Jenkins and Tim LaHaye

Skipping Christmas by John Grisham

A Painted House by John Grisham

Dreamcatcher by Stephen King

The Corrections by Jonathan Franzen

Black House by Stephen King and Peter Straub

The Kiss by Danielle Steel

Valhalla Rising by Clive Cussler

A Day Late and a Dollar Short by Terry McMillan

Violets Are Blue by James Patterson

2002

The Summons by John Grisham

Red Rabbit by Tom Clancy

The Remnant by Jerry B. Jenkins and Tim LaHaye

The Lovely Bones by Alice Sebold

Prey by Michael Crichton

Skipping Christmas by John Grisham

The Shelters of Stone by Jean M. Auel

Four Blind Mice by James Patterson

Everything's Eventual: 14 Dark Tales by Stephen King

The Nanny Diaries by Emma McLaughlin and Nicola Kraus

2003

The Da Vinci Code by Dan Brown

The Five People You Meet in Heaven by Mitch Albom

The King of Torts by John Grisham

Bleachers by John Grisham

Armageddon by Tim LaHaye and Jerry B. Jenkins

The Teeth of the Tiger by Tom Clancy

The Big Bad Wolf by James Patterson

Blow Fly by Patricia Cornwell

The Lovely Bones by Alice Sebold

The Wedding by Nicholas Sparks

2004

The Da Vinci Code by Dan Brown

The Five People You Meet in Heaven by Mitch Albom

The Last Juror by John Grisham

Glorious Appearing by Jerry B. Jenkins and Tim LaHaye

Angels & Demons by Dan Brown

State of Fear by Michael Crichton

London Bridges by James Patterson

Trace by Patricia Cornwell

The Rule of Four by Ian Caldwell and Dustin Thomason

The Da Vinci Code: Special Illustrated Collector's Edition by Dan Brown

2005

The Broker by John Grisham

The Da Vinci Code by Dan Brown

Mary, Mary by James Patterson

At First Sight by Nicholas Sparks

Predator by Patricia Cornwell

True Believer by Nicholas Sparks

Light from Heaven by Jan Karon

The Historian by Elizabeth Kostova

The Mermaid Chair by Sue Monk Kidd

Eleven on Top by Janet Evanovich

2006

For One More Day by Mitch Albom

Cross by James Patterson

Dear John by Nicholas Sparks

Next by Michael Crichton

Hannibal Rising by Thomas Harris

Lisey's Story by Stephen King

Twelve Sharp by Janet Evanovich

Cell by Stephen King

Beach Road by James Patterson and Peter de Jonge

The 5th Horseman by James Patterson and Maxine Paetro

2007

A Thousand Splendid Suns by Khaled Hosseini

Playing For Pizza by John Grisham

Double Cross by James Patterson

The Choice by Nicholas Sparks

Lean Mean Thirteen by Janet Evanovich

Plum Lovin' by Janet Evanovich

Book of the Dead by Patricia Cornwell

The Quickie by James Patterson and Michael Ledwidge

The 6th Target by James Patterson and Maxine Paetro

The Darkest Evening of the Year by Dean Koontz

2008

The Appeal by John Grisham

The Story of Edgar Sawtelle by David Wroblewski

The Host by Stephenie Meyer

Cross Country by James Patterson

The Lucky One by Nicholas Sparks

Fearless Fourteen by Janet Evanovich

Christmas Sweater by Glenn Beck

Scarpetta by Patricia Cornwell

Your Heart Belongs to Me by Dean Koontz

Publishers Weekly list of bestselling novels in the United States in the 2000s