The 1995 American League Division Series (ALDS), the opening round of the 1995 American League playoffs, began on Tuesday, October 3, and ended on Sunday, October 8, with the champions of the three AL divisions—along with a "wild card" team—participating in two best-of-five series. As a result of both leagues realigning into three divisions in 1994, it marked the first time in major league history that a team could qualify for postseason play without finishing in first place in its league or division. The teams were:

Seattle Mariners (Western Division champion, 79–66) vs. New York Yankees (Wild Card, 79–65): Mariners win series, 3–2. Boston Red Sox (Eastern Division champion, 86–58) vs. Cleveland Indians (Central Division champion, 100–44): Indians win series, 3–0.

1995 American League Division Series

The format of this series and the NLDS was the same as the League Championship Series prior to 1985, a five-game set wherein the first two games were played at one stadium and the last three at the other. This format was later changed in 1998 for the present 2–2–1 format, which has been used in the Division Series since except for 2012, when the 2–3 format was used again due to the addition of the Wild Card Game. Because of realignment, this was the first time that both the Yankees and the Red Sox reached the playoffs in the same year.

1995 American League Division Series

The Seattle Mariners and Cleveland Indians went on to meet in the AL Championship Series (ALCS). The Indians became the American League champion and lost to the National League champion Atlanta Braves in the 1995 World Series.

1995 American League Division Series

Matchups

Boston Red Sox vs. Cleveland Indians

Seattle Mariners vs. New York Yankees

Boston vs. Cleveland

Game 1

Jacobs Field in Cleveland, Ohio

After a 39-minute rain delay, Game 1 got underway with two veterans, Roger Clemens and Dennis Martínez, starting the opener. Playing in its first playoff game since Game 4 of the 1954 World Series, Cleveland trailed early as the Red Sox jumped in front first in the third on John Valentin's two-run homer. The Indians, however, rallied against Clemens in the sixth with two two-out singles followed by a two-run double by Albert Belle that tied the game and a single by Eddie Murray that scored Belle. But Luis Alicea's eighth inning home run off of Julián Tavárez sent the game into extra innings. Tim Naehring would give the Red Sox the lead in the 11th with a home run off of Jim Poole, but Belle's leadoff home run off of Rick Aguilera tied the game in the bottom half. The Indians would put the winning run in scoring position later in the inning but failed to come through. In the bottom of the 13th, 15-year veteran Tony Peña hit the game winning homer with two outs. It was the Indians' first postseason win since the clinching Game 6 in the 1948 World Series.

Game 2

Jacobs Field in Cleveland, Ohio

Game 2 featured an unlikely matchup between Erik Hanson and Orel Hershiser. Both pitchers were on even turns until the Indians broke through in the fifth with Omar Vizquel's two-run double after two walks. It remained 2–0 until the eighth when the Indians put the game away on Eddie Murray's two-run home run after a walk. That gave the Indian bullpen a comfortable 4–0 lead in the ninth. Hanson pitched a complete game in a losing effort. Hershiser struck out seven and allowed only three hits in innings.

Game 3

Fenway Park in Boston, Massachusetts

Charles Nagy faced Tim Wakefield in the potential clincher. In the top of the second, with a man on first, Jim Thome gave the Tribe the lead with a two-run home run just inside the Pesky Pole. Thome later drew a bases-loaded walk in the third to make it 3–0. In the fourth, the Red Sox loaded the bases on three singles with one out, but scored only one run on Mike Macfarlane's sacrifice fly. The Indians blew the game open in the sixth. After a single and walk, Paul Sorrento's single and Sandy Alomar's double scored a run each and knocked Wakefield out of the game. Rhéal Cormier in relief struck out Kenny Lofton, but Omar Vizquel's singled scored two and Carlos Baerga's double scored another. In the eighth, the Red Sox again loaded the bases on three one-out singles, but again only scored once on Willie McGee's fielder's choice off of Julián Tavárez. Paul Assenmacher would pitch a scoreless ninth to end the series. The loss was the Red Sox 13th consecutive postseason loss dating back to Game 6 of the 1986 World Series.