The 1949 U.S. Women's Open was the fourth U.S. Women's Open, held September 22–25 at Prince George's Country Club in Landover, Maryland, a suburb east of Washington, D.C.
Louise Suggs led wire-to-wire and won the first of her two U.S. Women's Open titles, fourteen strokes ahead of runner-up Babe Zaharias, the defending champion. It was the fourth of eleven major championships for Suggs.
The course no longer exists and is now the site of Kentland Community Center Park.