Her heart was now truly engaged to God, so she laid her coronet at the Redeemer’s feet, and resolved, according to her ability, to lay herself out to do good. In 1738, when John and Charles Wesley preached in the neighbourhood of Donnington Park, she sent a kind message to them, acknowledging that she was one at heart with them, bidding them good speed in the name of the Lord, and assuring them of her determination to live for Him who had died for her. The oratory of the Methodists was fervid and powerful; and the spiritual fire which glowed within, animated their discourses, and attracted many to the standard of the cross. The number of ordained ministers was insufficient to meet the demands for their services. But a new agency was now springing up: holy and gifted laymen began to preach, and their labours were crowned with greater success than those of the most illustrious men sent from colleges and universities. It should never be forgotten that we owe all the blessings which the world has received from lay preachers chiefly to the good sense and spiritual discernment of Lady Huntingdon.
In the summer of 1743, the Earl and Countess of Huntingdon, with the Ladies Hastings, visited Yorkshire, where the work of the Lord was making great progress. Soon after her return she was called upon to endure severe domestic trials. Two of her beloved sons died within a short period of each other, one aged thirteen, and the other aged ten years. In April, 1746, Lady Huntingdon was attacked by a serious illness; but by the skill of her medical attendants, and the blessing of God, she was restored to health and strength. Scarcely had she recovered from the loss of her children, and her own illness, before she was bereaved of her husband, Lord Huntingdon, who died at his house in Downing Street, Westminster, October 13th, 1746. But these and subsequent personal and family afflictions only awakened her mind toward religious concernments, and caused her to be more energetic in the diffusion of Christian principles. Lord Huntingdon left his widow in uncontrolled command of an income amply sufficient for maintaining her position, with her surviving children, in the style which befitted her rank; but confining her expenditure within narrow limits, she regarded her fortune as a trust which it was her happiness to administer in furtherance of the highest purposes.