The 2010 season was the Arizona Cardinals' 91st in the National Football League (NFL) and their 23rd in Arizona. The Cardinals attempted to improve on their 10–6 record from 2009. But after a modest 3–2 start, the Cardinals fell apart by losing 9 of their remaining 11 contests. They were eliminated from postseason contention for the first time since 2007 in Week 15.

Offseason

Quarterback Kurt Warner announced his retirement on January 29, 2010.

2010 Arizona Cardinals season

2010 NFL Draft

After finishing the season with a loss in the divisional round of the postseason, the Cardinals will pick 26th. The Cardinals will also have an additional third and fourth round pick from a trade that sent wide receiver Anquan Boldin to the Baltimore Ravens. Their fourth round pick was traded to the New York Jets for safety Kerry Rhodes.

2010 Arizona Cardinals season

Staff and roster

Coaching staff

Final roster

Preseason

Schedule

Regular season

Standings

Regular season results

Week 1: at St. Louis Rams

The Cardinals began their season at the Edward Jones Dome for an NFC West match against the St. Louis Rams. The Cardinals scored first in the 2nd quarter with kicker Jay Feely nailing a 22-yard field goal, which was replied by St. Louis when kicker Josh Brown made a 46-yard field goal. Arizona took the lead again with running back Tim Hightower making a 1-yard TD run, but failed to maintain it, with quarterback Sam Bradford making a 1-yard TD pass to wide receiver Laurent Robinson. In the third quarter, the Cardinals trailed for the first time when Brown nailed a 25-yard field goal, which they overcame in the fourth quarter when quarterback Derek Anderson made a 21-yard touchdown pass to wide receiver Larry Fitzgerald, giving Arizona a win.

2010 Arizona Cardinals season

With the win, Arizona began the season at 1–0.

Week 2: at Atlanta Falcons

Hoping to maintain their current winning streak the Cardinals flew to Georgia Dome for an NFC duel with the Falcons. In the first quarter Arizona trailed early as QB Matt Ryan completed a 7-yard TD pass to WR Roddy White, followed in the second quarter by kicker Matt Bryant hitting a 24-yard field goal. Arizona would reply with RB Tim Hightower getting an 80-yard TD run, but fell further behind when Ryan threw a 19-yard TD pass to FB Jason Snelling, followed by Snelling getting a 1-yard TD run. In the third quarter the Cardinals struggled further when Ryan completed a 12-yard touchdown pass to WR Brian Finneran, followed by Bryan nailing a 35-yard field goal. In the fourth quarter Arizona continued to struggle with FB Jason Snelling getting a 7-yard TD run.

With the loss, the Cardinals fell to 1–1.

Week 3: vs. Oakland Raiders

The Cardinals' third game was an Interconference duel with the Raiders. The Cardinals led early in the first quarter when RB LaRod Stephens-Howling returned a kickoff from his own goal line to the endzone running 102 yards for a touchdown. The Raiders replied and took the lead with QB Bruce Gradkowski completing a 22-yard touchdown pass to TE Zach Miller, followed by kicker Sebastian Janikowski making a 22-yard field goal. Arizona replied with kicker Jay Feely kicking a 42-yard field goal. Then the Raiders replied with Janikowski making a 54-yard field goal. The Cardinals took the lead in the 2nd quarter when QB Derek Anderson made a 2-yard TD pass to WR Steve Breaston, but it didn't last very long after RB Darren McFadden got a 2-yard TD run. Arizona got the lead back in the 3rd quarter when Anderson found WR Larry Fitzgerald on an 8-yard TD pass. In the 4th quarter Oakland cut the lead when Janikowski made a 23-yard field goal. Janikowski missed three field goals in the game, giving Arizona the win.

With the close win, Arizona improved to 2–1.