On the contrary, if the opium or aloes be exhibited in a large dose at first, so as to produce intoxication or diarrhoea; after a few repetitions the quantity of either of them may be diminished, and they will still produce this effect. For the more powerful stimulus dissevers the progressive catenations of animal motions, described in Sect. XVII. and introduces a new link between them; whence every repetition strengthens this new association or catenation, and the stimulus may be gradually decreased, or be nearly withdrawn, and yet the effect shall continue; because the sensorial power of association or catenation being united with the stimulus, increases in energy with every repetition of the catenated circle; and it is by these means that all the irritative associations of motions are originally produced.
2. When a stimulus is repeated at such distant intervals of time, that the natural quantity of sensorial power becomes completely restored in the acting fibres, it will act with the same energy as when first applied. Hence those who have lately accustomed themselves to large doses of opium by beginning with small ones, and gradually increasing them, and repeating them frequently, as mentioned in the preceding paragraph; if they intermit the use of it for a few days only, must begin again with as small doses as they took at first, otherwise they will experience the inconveniences of intoxication.
On this circumstance depend the constant unfailing effects of the various kinds of stimulus, which excite into action all the vascular systems in the body; the arterial, venous, absorbent, and glandular vessels, are brought into perpetual unwearied action by the fluids, which are adapted to stimulate them; but these have the sensorial power of association added to that of irritation, and even in some degree that of sensation, and even of volition, as will be spoken of in their places; and life itself is thus carried on by the production of sensorial power being equal to its waste or expenditure in the perpetual movement of the vascular organization.
3. When a stimulus is repeated at uniform intervals of time with such distances between them, that the expenditure of sensorial power in the acting fibres becomes completely renewed, the effect is produced with greater facility or energy. For the sensorial power of association is combined with the sensorial power of irritation, or, in common language, the acquired habit assists the power of the stimulus.