The 2021–22 Derde Divisie season was the sixth edition of the Dutch fourth tier, formerly called Topklasse, since the restructuring of the league system in the summer of 2016.
Saturday league
Teams
Number of teams by province
Standings
Fixtures/results
Sunday league
Teams
Number of teams by province
Standings
Fixtures/results
Promotion/relegation play-offs
Derde Divisie promotion/relegation playoffs
Since Kozakken Boys and GVVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Derde Divisie for one spot in the 2022–23 Tweede Divisie.
Bracket
Quarterfinals
First legs
Second legs
Semifinals
First legs
Second legs
Final
First leg
Second leg
Hoofdklasse saturday promotion/relegation playoffs
Since ODIN '59 and VVOG finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Hoofdklasse Saturday for two spots in the 2022–23 Derde Divisie.
Brackets
Semifinals
First legs
Second legs
Finals
First legs
Second legs
Hoofdklasse sunday promotion/relegation playoffs
Since Hoogland and EVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Hoofdklasse Sunday for two spots in the 2022–23 Derde Divisie.