Big Muddy may refer to:
Places
Big Muddy, Wyoming, U.S. Big Muddy Badlands, Saskatchewan, Canada, and Montana, U.S.
Waterways
Big Muddy Creek (Missouri River tributary), Saskatchewan, Canada, and Montana, U.S. Missouri River, nicknamed "Big Muddy" Mississippi River, nicknamed "The Big Muddy" Big Muddy River, Illinois, U.S. Big Muddy Creek (New Zealand), near the Upper Nihotupu Reservoir Big Muddy Lake, a lake in Saskatchewan
Other uses
Big Muddy (film), a 2015 Canadian crime drama
Big Muddy National Fish and Wildlife Refuge, along the Missouri River, U.S. Big Muddy oil field, Wyoming, U.S. Big Muddy Ranch Airport, Antelope, Oregon, U.S. Big Muddy Records, an independent American music record label Big Muddy River Correctional Center, in Ina, Jefferson County, Illinois Weyburn-Big Muddy, an electoral district in Saskatchewan, Canada "Big Muddy", a song by Bruce Springsteen from the 1992 album Lucky Town