The 2010 season for began in January with the Tour Down Under and ended in October at the Chrono des Nations. As a UCI ProTour team, they were automatically invited and obliged to send a squad to every event in the ProTour.
2010 roster
Ages as of January 1, 2010.
Riders who joined the team for the 2010 season
Riders who left the team during or after the 2009 season
One-day races
Spring classics
Fall races
Stage races
The team attended the Tour Down Under, with a squad headed by Jürgen Roelandts, who did not win any stage but did win the best young rider competition.
Grand Tours
Giro d'Italia
Omega Pharma-Lotto came to the Giro with a young squad – Bakelandts, Blythe, and De Greef were all eligible for the youth classification, and Wegelius was the only rider older than 30 – headed by Lang. Their outside contender for the general classification was Moreno, and Elijzen was included on the squad with the time trials in mind. In stage 3 in the Netherlands, Blythe made the late selection for a depleted group sprint finish, taking fifth, one spot ahead of the season's most prolific winner André Greipel. The squad's best-placed rider prior to the transfer to Italy was Lang in 33rd. The squad rode solidly in the stage 4 team time trial, finishing with seven riders (only Elijzen and Blythe fell off the pace) in a seventh place time 46 seconds off the pace of stage winners .
In stage 6, Lloyd and rider Rubens Bertogliati formed the day's principal breakaway after . Lloyd led Bertogliati over the day's first two climbs before breaking free of him before the last. He soloed over the Bedizzano and, later, the finish line, winning the stage 1'15" ahead of the peloton. Lloyd also took the green jersey as mountains classification leader with the day's results. Lloyd made early morning breakaways in stages 8, 11, and 20 to take mountains points on climbs early in the course those days. Lloyd wore the green jersey for the rest of the Giro, winning the classification in Verona at the Giro's conclusion. Lloyd also won the combativity classification, an award determined by points given for riders' positions in stage finishes, mountain climbs, and intermediate sprints.
Lloyd's victories were the only ones the squad attained. Bakelandts finished in the top ten on the very difficult, muddy stage 7 in Tuscany and again in stage 11, when a 50-rider breakaway led to massive changes in the overall standings. Lang made a winning breakaway in stage 13, finishing fifth in the sprint for the stage win. Elijzen took eighth in the Giro's final field sprint, in stage 18. The squad finished fifth in the Trofeo Fast Team standings and 16th in the Trofeo Super Team.
Tour de France
Omega Pharma-Lotto's squad leader at the Tour de France was Van Den Broeck, who hoped to finish the race in the top ten after a 15th place in the 2009 event. They rode without Gilbert, who was concentrating on the Vuelta a España later in the season, and without French national time trial champion Péraud, who was not yet recovered from injuries sustained in the Critérium du Dauphiné.
The squad did little on the first three days of the Tour, taking a couple of meaningless top placings with Roelandts on stages which both involved neutralizations. In stage 3, which covered several cobbled sectors in an area on the border between Belgium and France, Van Den Broeck finished with the second group on the road, 53 seconds behind the stage winner. This was good for ninth on the day and propelled him from 33rd overall up to tenth, as many riders who had been ahead of him, including some overall favorites, lost significant time. The overall standings did not change again until stage 7, which ended at Station des Rousses in the Jura, the first stage with any significant amount of climbing. Van Den Broeck finished with the elite riders in the race. His time gaps to his rivals were unchanged, but since Fabian Cancellara, Geraint Thomas, and Thor Hushovd, who had been ahead of him, finished well back, he moved up to seventh overall. Also on this stage, Moreno followed a move instigated by Pierrick Fédrigo in the final kilometer and finished 7 seconds ahead of the peloton, for sixth on the day. Van Den Broeck was on good form again the next day in a more mountainous stage, finishing with the elite riders again. While he was part of a nine-rider group who lost ten seconds to Andy Schleck and Samuel Sánchez, who aggressively sought the stage win, he moved up a further four places with this result, occupying fourth overall before the Tour's first rest day.