Melrose is a historic home located in the Murfreesboro Historic District at Murfreesboro, Hertford County, North Carolina. It was built about 1805, as a two-story, Federal style brick dwelling with a gable roof and interior end chimneys. Two-story, two bay, Greek Revival style wings were added in the mid-19th century. It is seven bays wide and features a tetrastyle portico supported by Ionic order columns and a Second story semi-circular balcony. It was built by Congressman William H. Murfree (1781 – 1827), son of Hardy Murfree (1752 – 1809).
It was listed on the National Register of Historic Places in 1971.