There are three business routes of US Highway 10 (US 10) in the state of Michigan. They serve as connections from the main highway into Reed City, Clare, and Midland. Additionally, there were another two business routes that connected US 10 to the downtowns of Flint and Pontiac. All these business routes are, or were, former sections of US 10 that were marked Business US Highway 10 (Bus. US 10) after the main highway was realigned to bypass the downtowns of the cities.

The Reed City Bus. US 10 was created by 1960 to follow Chestnut and Church streets into the community's central business district and through adjacent residential areas. In 1975 when US 10 was rerouted to follow the freeways around Clare, the former routing through downtown on McEwan and Fifth streets was redesignated as a business loop; it was also signed to provide connections between US 10 and what is now US 127 because of an incomplete interchange between those two freeways. The Midland business loop dates back to 1961 and follows Eastman Avenue and two sets of one-way streets before completing its routing as a freeway. The two business loops created for Flint and Pontiac were designated in 1941 and 1961, respectively. They followed streets that were once part of US 10, but, after additional changes to US 10's routing in Michigan, they were renumbered as business loops of other highways in 1962 and 1986, respectively. Near Flint, part of US 10 was replaced by M-54 when the US Highway was moved to a freeway, and, near Pontiac, it was replaced by US 24 after US 10 was truncated in the state.

Business routes of U.S. Route 10 in Michigan

Reed City

Business US Highway 10 (Bus. US 10) is an east–west business loop running for about in Reed City. Running eastbound, the business loop starts at the corner of US 10 and Chestnut Street and runs southward along the latter into downtown. Chestnut Street is old US 131 and passes through some residential neighborhoods. It also crosses the Hersey River and the Pere Marquette State Trail while running parallel to the White Pine Trail along its western half. At the intersection with Church Street near Reed City High School, Bus. US 10 turns eastward. The business loop continues easterly out of downtown and angles northeasterly before crossing the Hersey River and the Pere Marquette State Trail again. Immediately to the northeast of the river crossing, Bus. US 10 intersects its parent highway and terminates. The entire route of the highway follows two-lane streets through town. According to the Michigan Department of Transportation (MDOT), the agency which maintains the roadway, between 1,949 and 5,499 vehicles per day used the business loop on average daily in 2013.

Business routes of U.S. Route 10 in Michigan

In 1919 when the state highway system was first numbered, the east–west highway running through Reed City was numbered M-20, and it was renumbered to US 10 seven years later when the US Numbered Highway System was created. The business loop was created after US 10 was moved to bypass downtown Reed City in the late 1950s. This realignment was completed, and the business loop commissioned, by 1960. Until 1986, the western half of the loop along Chestnut Street ran concurrently with US 131 until that highway was moved to its current freeway routing.

Business routes of U.S. Route 10 in Michigan

Major intersections

Clare

Business US Highway 10 (Bus. US 10) is a business loop in Clare that is just over long. From its western end, it branches off its parent highway, US 10, and runs southward into the city of Clare. Because US 10 runs concurrently with US 127 on the northern and eastern sides of Clare, Bus. US 10 is also concurrent with Bus. US 127 on its western leg. Bus. US 10/Bus. US 127 follows McEwan Street southward over the South Branch of the Tobacco River and through a residential area on the north side of the city. Several blocks further south, the highway enters the downtown district and turns onto Fifth Street, separating from Bus. US 127.

Fifth Street continues eastward and then southeasterly out of downtown and through residential areas. At Clarabella Road, the business loop crosses from Clare County into Isabella County before passing under the US 127 freeway without an interchange. Bus. US 10 runs parallel to the Pere Marquette Rail-Trail on Saginaw Road in a rural section of Isabella County before terminating at an interchange that connects it to eastbound US 10 in Wise Township. Through the city, the business loop has four lanes for traffic, but the rural segment in Isabella County has two. According to MDOT, the agency which maintains the roadway, between 4,035 and 6,540 vehicles per day used the business loop on average daily in 2013.