It would be strange indeed, if, as is generally supposed, the Indian aborigines of South America were ignorant of the virtues of Peruvian bark; yet the absence of this sovereign remedy in the wallets of itinerant native doctors who have plied their trade from father to son, since the time of the Incas, certainly gives some countenance to this idea. It seems probable, nevertheless, that the Indians were aware of the virtues of Peruvian bark in the neighbourhood of Loxa, 230 miles south of Quito, where its use was first made known to Europeans: and the Indian name for the tree _quina-quina_, "bark of bark," indicates that it was believed to possess some special medicinal properties.[3] The Indians looked upon their conquerors with dislike and suspicion; it is improbable that they would be quick to impart knowledge of this nature to them; and the interval which elapsed between the discovery and settlement of the country and the first use of Peruvian bark by Europeans may thus easily be explained.[4] The conquest and subsequent civil wars in Peru cannot be said to have been finally concluded until the time of the viceroy Marquis of Cañete, in 1560; and J. de Jussieu reports that a Jesuit, who had a fever at Malacotas,[5] was cured by Peruvian bark in 1600. M. La Condamine also found a manuscript in the library of a convent at Loxa, in which it was stated that the Europeans of the province used the bark at about the same time. Thus an interval of only forty years intervened between the pacification of Peru and the discovery of its most valuable product.
It may be added, however, that though the Indians were aware of the febrifugal qualities of this bark, they attached little importance to them, and this may be another reason for the lapse of time which occurred before the knowledge was imparted to the Spaniards. Referring to this circumstance La Condamine says, "Nul n'est saint dans son pays." This indifference to, and in many cases even prejudice against the use of the Peruvian bark, amongst the Indians, is very remarkable. Poeppig, writing in 1830, says that in the Peruvian province of Huanuco the people, who are much subject to tertian agues, have a strong repugnance to its use. The Indian thinks that the cold north alone permits the use of fever-bark; he considers it as very heating, and therefore an unfit remedy in complaints which he believes to arise from inflammation of the blood.[6] Humboldt also notices this repugnance to using the bark amongst the natives; and Mr. Spruce makes the same observation with respect to the people of Ecuador and New Granada.[7] He says that they refer all diseases to the influence of either heat or cold; and, confounding cause and effect, they suppose all fevers to proceed from heat. They justly believe bark to be very heating, and hence their prejudice against its use in fevers, which they treat with _frescos_ or cooling drinks. Even in Guayaquil the prejudice against quinine is so strong that, when a physician administers it, he is obliged to call it by another name.