The Centenary Methodist Episcopal Church, South in St. Louis, Missouri is a Gothic Revival church that was built in 1869. It was listed on the National Register of Historic Places in 1997.
The building is a two-story limestone church linked with a three-story office/service building. It was designed by Baltimore architect Thomas Dixon and its construction was supervised by local architect Jerome B. Legg. A three-story brick and stone addition to the west was added in 1924, designed by St. Louis architects Mauran, Russell & Crowell.