A list of notable people from Alappuzha:
Academia and science
Tessy Thomas - DRDO
Itty Achudan - the major contributor of ethno-medical information for the compilation of Hortus Malabaricus Illiparambil Corah Chacko - geologist Pallithanam Luca Matthai - pioneer of kayal cultivation in Kuttanad, and former member of Sree Moolam Popular Assembly Sreedhara Panicker Somanath - Current Chairman of the Indian Space Research Organisation
Arts and entertainment
Film and stage
K. Madhu - film director, film producer, actor
Saranya Ponvannan - actor
Parvathy Jayaram - actor
Mammootty - actor
Navodaya Appachan (Chacko Punnoose) - film producer, director, and entrepreneur
Ashokan - Malayalam film actor, 1978–
Thoppil Bhasi - playwright, screenwriter, and film director
Kunchako Boban - film actor
Riaz M T - Film Actor
Rajan P. Dev - Malayalam film actor
Fazil - film director
Fahad Fazil - film actor
Chelangatt Gopalakrishnan - film critic and writer
Kunchacko - film producer and director
K. P. A. C. Lalitha - film actress
Balachandra Menon - film actor, director, script writer
Navya Nair - film actress in Malayalam, Tamil, and Kannada films
Padmarajan - film director, script writer, story writer
Chenganoor Raman Pillai - stage actor
Muthukulam Raghavan Pillai - dramatist, film actor, poet
Narendra Prasad - actor, playwright, and director
Priyadarshan - film director
Ratheesh - film actor
M. G. Sreekumar - playback singer and film music director
Sreekumaran Thampi - lyricist, director, producer, script writer
Vayalar Sarath Chandra Varma - film lyricist
Nedumudi Venu - film actor
Vinayan - film director
Saranya Mohan - film actor
Aarsha Chandini Baiju - film actress
Graphic arts
K. Shankar Pillai - cartoonist (Shankar)
Literature
Eleanour Sinclair Rohde - British gardener and writer on gardening
Joy J. Kaimaparamban - English and Malayalam author
Ayyappa Paniker - poet
Kavalam Narayana Panicker - poet
Parappurath (K. E. Mathai) - novelist and short story writer
Thakazhi Sivasankara Pillai - novelist and short story writer
Vayalar Ramavarma- Malayalam poet and film lyricist
K. P. Sasidharan- Malayalam writer and academician
Lopamudra R - Malayalam Poet and Translator
Music
Mavelikkara Velukkutty Nair - mridangam player
Palani Subramaniam Pillai - percussionist, played the mridangam and kanjira
Erickavu N. Sunil - mridangam player
Mavelikkara Prabhakara Varma - Carnatic singer
Commerce and business
Bhima Bhattar - founder of Bhima Jewellers at Mullakkal, Alleppey
Judiciary
Justice CT Ravikumar,Judge Supreme Court of India
Politics, government, and social welfare
V. S. Achuthanandan - former Chief Minister and current leader of opposition of Kerala K. R. Gowri Amma - Revenue Minister in the first Kerala LDF ministry, initiated the revolutionary land reforms in Kerala, Agriculture Minister in Kerala UDF Ministry A. K. Antony - Three-time Chief Minister of Kerala, Former Indian Defence Minister Ramesh Chennithala - politician, former Member of Parliament T. K. Madhavan (1885—1930) social reformer, journalist and revolutionary Pallithanam Luca Matthai - Former member of Sree Moolam Popular Assembly and pioneer of kayal cultivation in Kuttanad Kavalam Madhava Panikkar - diplomat, administrator, historian P. Parameswaran - director of Bharathiya Vichara Kendram and president of Vivekananda Kendram Vayalar Ravi - former Home minister of Kerala, Union Cabinet Minister of Overseas Indian Affairs and Minister for Parliamentary Affairs C. M. Stephen - politician and Union minister
Religion
Baselios Thoma Didymos I - Catholicos of the East and Malankara Metropolitan
Kuriakose Elias Chavara - Blessed, co-founder of CMI
James Kalacherry - Bishop of Changanacherry, who campaigned against the move by C. P. Ramaswami Iyer, the Diwan of Travancore in 1945, to nationalise all schools Navajyothi Sree Karunakara, the founder of Santhigiri Ashram Mar Thomas Kurialachery - Venerable, first bishop of what would become the Archdiocese of Changanassery, and founder of the Sisters of the Adoration of the Blessed Sacrament