He had been in Virginia but a few months when word reached him of the outbreak of the Civil War in England. He must have been horrified that anyone should dare to take up arms against the sacred person of the King, and he sought permission to return to England to defend him. So, in the summer of 1644, when Charles was bearing down on the Parliamentary forces under Essex in Cornwall, Berkeley was with him. And he looked on with deep satisfaction as Sir Richard Grenville ransacked Lord Roberts' house at Lanhydrock, eight miles north of Fowey, and made off with silver plate worth £2000.
It was probably soon after this that word came of the terrible Indian massacre of April 18, 1644, for Berkeley was back in Virginia on June 7, 1645. Placing himself at the head of the forces which had been bringing fire and destruction to the Indian villages, he soon forced the savages to seek refuge in the woods and swamps. After he had captured their aged chief Opechancanough, they sued for peace.
Upon receiving news of the execution of Charles I, Sir William proclaimed Charles II King. And when, in 1652, a Parliamentary fleet sailed up the James to reduce the colony, he summoned the militia and prepared for a stubborn resistance. It was only when his Council pointed out the folly of defying the might of Britain that he reluctantly agreed to surrender. But his soul was filled with bitterness. So, with the restoration of Charles II to the throne, when once more he was governor of Virginia, he was determined to permit no more of representative government than his commission and instructions made necessary.
This he did by corrupting the Burgesses and continuing them by prorogations for many years. He took on himself "the sole nominating" of all civil and military officers, picking out such persons as he thought would further his designs. Collectors', sheriffs', justices' places were handed out to the Burgesses with a lavish hand. The list of Burgesses in the so-called Long Assembly sounds like a military roll call, for of the thirty members in 1666, six were colonels of militia, two lieutenant-colonels, one a major, and fourteen captains. Philip Alexander Bruce states that "a large proportion of the justices were also members of the House of Burgesses." In this way he "gained upon and obliged" the "men of parts and estates" in the Burgesses, and made them subservient to his will. "He has so fortified his power over us as of himself without respect to our laws to do what so ever he pleased," it was said.