People sanitizing at bus station to prevent COVID-19 in Rwanda, March 23, 2021. Photo by Davyimage via Wikimedia Commons (CC BY-SA 4.0). COVID-19 vaccination in much of Africa has lost momentum in recent months. Though vaccine shipments to the continent have increased in 2022 — more than doubling from November 2021 to January 2022 — the number of vaccine doses administered fell by 35 percent between February and March 2022. Rollouts have been slow, for a variety of reasons including logistical challenges related to vaccine storage and distribution, vaccine hesitancy, and a perception that COVID-19 is not a serious threat. Lower vaccination rates mean lower protection against the virus, particularly if newer and potentially more transmissive or deadly variants emerge. To regain momentum, African governments will need to take a multifaceted approach and manage relations with external stakeholders to obtain the necessary support. From a glance at a map showing global COVID-19 vaccination rates, it is apparent that countries in Sub-Saharan Africa lag well behind most of the world. While many countries in Asia, Europe, and the Americas have vaccinated more than 60 percent of their population, most of Africa falls well short of this threshold. In some countries, such as Burundi, the rate is below 1 percent. There are also outliers in the region. One is Burundi’s neighbor Rwanda, where more than 60 percent of citizens have received two doses. Another is Botswana, where more than half of the population is fully vaccinated. The reasons behind Rwanda and Botswana’s COVID-19 vaccination success stories mostly come down to rigorous planning. In April 2021, pediatrician and former health minister Agnes Binagwaho explained that Rwandan’s high coronavirus vaccination rates benefited from reaching an agreement early on with COVAX, a multilateral initiative to ensure equitable access to COVID-19 vaccines. In addition, Rwanda prepared its logistical capacity to store and deliver vaccines, set up plenty of vaccination sites, and trained healthcare workers. Botswana was similarly robust in its planning and coordination of vaccine rollouts in that it tapped multiple sectors, set up local liaison offices, and collected data to develop monitoring and evaluation tools. It also launched a communications campaign to address vaccine hesitancy and misinformation in March 2021. Going forward, African countries should aim to both boost vaccine production on the continent, so that they do not have to rely on donations or exports from further afield, and improve vaccine intake. Botswana announced in March 2022, the construction of a plant to produce the Corbevax vaccine, in collaboration with South African-American businessman Patrick Soon-Shiong’s holding company NantWorks. However, this plant will only be operational in 2026, so will not be able to meet Africa’s immediate needs. South African company Aspen Pharmacare also secured an agreement to manufacture Johnson & Johnson’s vaccine, but has not received any orders from African countries. If demand does not pick up, then plans to build facilities for manufacturing mRNA vaccines that offer the highest degree of protection against the virus — like the Moderna and Pfizer-BioNTech vaccines — in Kenya and South Africa may not be viable. To narrow gaps in vaccination rates with the rest of the world, African governments could learn from the success stories of Botswana and Rwanda. They could also collaborate with external powers including the United States, the European Union, China, and multilateral institutions. These foreign powers and institutions may support the construction of vaccine manufacturing and storage plants, or the development and expansion of innovative solutions. They can also help aid logistical challenges, such as Ghana efforts to deliver vaccines with drones, through funding and knowledge sharing. Children wearing masks to protect themselves against the coronavirus in Botswana, February 27, 2021. Photo by Aobakwe Absa Basupi via Wikimedia Commons (CC BY-SA 4.0). Rich countries rightly came under criticism for “hoarding” COVID-19 vaccines in 2021. To the extent that countries with access to vaccines have supplied them to lower- and middle-income countries in regions including Sub-Saharan Africa, they have often been driven by strategic goals and competition. Vaccine diplomacy, defined as the provision of vaccines to countries to gain geopolitical influence, is a short-sighted approach. Supplying vaccines to countries or supporting inoculation drives in other ways should not be seen as a zero-sum game, where one great power improves its standing in partner countries at the expense of others.