Pope Leo X (r. 1513–1521) created 42 new cardinals in eight consistories.
23 September 1513
All the new cardinals received their titles on 29 September 1513.
Lorenzo Pucci, bishop of Melfi – cardinal-priest of SS. IV Coronati, then cardinal-bishop of Albano (15 June 1524), cardinal-bishop of Palestrina (24 July 1524), † 16 September 1531 Giulio de’ Medici, cousin of the Pope, archbishop of Florence – cardinal-deacon of S. Maria in Domnica, then cardinal-priest of S. Clemente (2 June 1517), cardinal-priest of S. Lorenzo in Damaso (6 July 1517), became Pope Clement VII on 19 November 1523, † 25 September 1534 Bernardo Dovizi – cardinal-deacon of S. Maria in Portico, † 1 November 1520 Innocenzo Cybo, nephew of the Pope – cardinal-deacon of SS. Cosma e Damiano, then cardinal-deacon of S. Maria in Domica (26 June 1517), cardinal-deacon of S. Maria in Via Lata (28 February 1550), † 1 April 1550
10 September 1515
Thomas Wolsey, archbishop of York – cardinal-priest of S. Cecilia, † 29 November 1530
14 December 1515
Adrian Gouffier de Boissy, bishop of Coutances – cardinal-priest of SS. Marcellino e Pietro, then cardinal-priest of S. Balbina (1518?), † 9 November 1520
1 April 1517
All the new cardinals received their titles on 25 May 1517
Antoine Bohier Du Prat, O.S.B., archbishop of Bourges – cardinal-priest of S. Anastasia, † 27 November 1519 Guillaume de Croÿ, bishop of Cambrai – cardinal-deacon of S. Maria in Aquiro, † 6 January 1521