Downtown Spruce Pine Historic District is a national historic district located at Spruce Pine, Mitchell County, North Carolina. The district encompasses 33 contributing buildings in the central business district of Spruce Pine. It was developed between 1909 and 1953, and includes notable examples of Early Commercial and Tudor Revival style architecture. Located in the district is the separately listed Gunter Building. Other notable buildings include the Spruce Pine Depot (1909), Crystal Place (1937), (former) Town Hall (1940), and Day's Drug Store (1950).
It was added to the National Register of Historic Places in 2003.