The Poughkeepsie School Building is a historic school building in Poughkeepsie, Arkansas, between Arkansas Highway 58 and Cherry Street. It is a single-story fieldstone building in the shape of an H, with front-gabled wings flanking a central horizontally-ridged section. The school was built in 1929–30, and is a well-preserved representative of a rural Arkansas stone school of the period.
The building was listed on the National Register of Historic Places in 1992, at which time it was still in use as a school.