The 2021 Tenerife Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Tenerife, Spain between 1 and 7 November 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 25 October 2021.
Other entrants
The following players received wildcards into the singles main draw: Feliciano López Daniel Rincón Fernando Verdasco
The following player received entry into the singles main draw using a protected ranking: Joris De Loore
The following players received entry from the qualifying draw: Yan Bondarevskiy David Ionel Vladyslav Orlov Alexander Shevchenko
The following player received entry as a lucky loser: Filip Jianu
Champions
Singles
Tallon Griekspoor def. Feliciano López 6–4, 6–4.
Doubles
Nuno Borges / Francisco Cabral def. Jeevan Nedunchezhiyan / Purav Raja 6–3, 6–4.