Spence is a surname. Notable people with the surname include:
Ara Spence (1793–1866), American judge from Maryland
Basil Spence (1907–1976), British architect
Brent Spence (1874–1967), American politician, attorney, and banker
Catherine Helen Spence, Australian reformer and suffragette
Charles Spence, experimental psychologist at the University of Oxford
Derek Spence (born 1952), Irish footballer
Djed Spence (born 2000), English footballer
E. Lee Spence, American author, editor, adventurer and underwater archaeologist
Errol Spence Jr., American boxer
Fiona Spence, British-Australian actress
Floyd Spence, American politician
George Spence (Canadian politician) (1880–1975), Canadian politician
George Spence (MP) (1787–1850), , British politician
George Spence (footballer, born 1877) (1877–?), Scottish footballer
George Spence (footballer, born 1904) (1904–?), English footballer
Gerry Spence, American trial lawyer
James Spence, Scottish Surgeon
Joe Spence (footballer born 1898), English footballer for Manchester United in the 1920s Joe Spence (footballer born 1925), English footballer for York City in the 1950s John Brodie Spence, South Australian banker and politician, brother of Catherine John S. Spence, American politician from Maryland John Selby Spence (Catholic bishop), American Catholic bishop John Spence (politician), British politician John Spence (musician), founding member of the band No Doubt Jonathan Spence, English historian Jordan Spence (disambiguation), several people Joseph Spence (author), English anecdotist Joseph Spence (musician), Bahamian guitarist and blues musician Julian Spence (1929–1990), American football player Kenneth Spence, prominent American psychologist Lansford Spence, Jamaican sprinter Lewis Spence, journalist and writer Linda Spence, Irish-Scottish cricketer Louie Spence, British dancer Michael Spence, American economist Nicky Spence, Scottish opera singer Noah Spence, American football player Phil Spence, American basketball player and coach Russell Spence, English race car driver Sam Spence (1927–2016), American composer and musician Shaun Spence (born 1991), Australian rugby player Sion Spence (born 2000), Welsh footballer Skip Spence, musician Steve Spence, American long-distance runner Thomas Spence, Radical democrat Toby Spence (born 1969), English tenor Vivienne Spence, Jamaican track and field athlete William Spence, Australian trade union leader and politician William Wallace Spence (1815–1915), American financier Willie Spence (1999–2022), American singer Wishart Spence, Canadian judge