Let $U_\zeta$ be a Lusztig quantum enveloping algebra associated to a complex semisimple Lie algebra $\mathfrak g$ and a root of unity $\zeta$. When $L,L'$ are irreducible $U_\zeta$-modules having regular highest weights, the dimension of $\operatorname{ Ext}^n_{ U_\zeta}(L,L')$ can be calculated in terms of the coefficients of appropriate Kazhdan-Lusztig polynomials associated to the affine Weyl group of $U_\zeta$. This paper shows for $L,L'$ irreducible modules in a singular block that $\dim\operatorname{ Ext}^n_{ U_\zeta}(L,L')$ is explicitly determined using the coefficients of parabolic Kazhdan-Lusztig polynomials. This also computes the corresponding cohomology for $q$-Schur algebras and many generalized $q$-Schur algebras. The result depends on a certain parity vanishing property which we obtain from the Kazhdan-Lusztig correspondence and a Koszul grading of Shan-Varagnolo-Vasserot for the corresponding affine Lie algebra.
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