The 2021 Open Città di Bari was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Bari, Italy between 22 and 28 November 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 15 November 2021.
Other entrants
The following players received wildcards into the singles main draw: Luca Nardi Oleksandr Ovcharenko Luca Potenza
The following player received entry into the singles main draw using a protected ranking: Filippo Baldi
The following players received entry from the qualifying draw: Fabrizio Andaloro Antoine Bellier Sebastian Fanselow Francesco Maestrelli
Champions
Singles
Oscar Otte def. Daniel Masur 7–5, 7–5.
Doubles
Lloyd Glasspool / Harri Heliövaara def. Andrea Vavassori / David Vega Hernández 6–3, 6–0.