Guignard is a surname. Notable people with the surname include:
Alberto da Veiga Guignard (1896–1962), Brazilian artist
Alexis Guignard, comte de Saint-Priest (1805–1851), French diplomat and historian André Guignard, Swiss engineer initially educated as a watchmaker Armand Charles Emmanuel Guignard, comte de Saint-Priest (1782–1863), French aristocrat Christelle Guignard (born 1962), retired French alpine skier Emmanuel Louis Marie Guignard, vicomte de Saint-Priest (1789–1881), French politician and diplomat during the Bourbon Restoration Eric J. Guignard (born 1975), author and publisher François-Emmanuel Guignard, comte de Saint-Priest (1735–1821), French politician and diplomat during the Ancien Régime and French Revolution Guillaume Emmanuel Guignard, vicomte de Saint-Priest (1776–1814), French émigré general who fought in the Russian army Léon Guignard (1852–1928), French botanist and pharmacist Jazz Guignard, popular Haitian jazz musician in the 1930s