The Female Brain is a 2017 American comedy film directed by Whitney Cummings and written by Neal Brennan and Cummings. It is based on the 2006 book The Female Brain by Louann Brizendine. The film stars Cummings, Sofía Vergara, Toby Kebbell, James Marsden, Deon Cole, Lucy Punch, Beanie Feldstein and Cecily Strong.

It had its world premiere at the Los Angeles Film Festival on June 17, 2017. It was released on February 9, 2018, by IFC Films.

The Female Brain (film)

Plot

Stoic and uptight, university neurologist Julia Brizendine (Whitney Cummings) compares the female and male brain. She thinks she can outsmart her emotions, much to her assistant Abby’s (Beanie Feldstein) exasperation. She is divorced and living with her parents and Abby self-medicates.

The Female Brain (film)

Realtor Lisa Hampton (Sofia Vergara) and her husband of 12 years, Steven (Deon Cole) have a son Tyler. Fearing their relationship has grown dull, Lisa tries to spice things up by going on a date and getting high. Nothing works so they consider separation.

The Female Brain (film)

Perfectionist Lexi Mercer (Lucy Punch), fusses over her boyfriend of 2–3 years, Adam Simmons (James Marsden). Friends with Steven, he is fine with how he looks and won't straighten his hair as she wants. They break up when Lexi insists examining a tumor on his back, which turns out to be benign.

Zoe Green-Basker (Cecily Strong), a sales manager at an advertising company, resents gender stereotyping. She is close to starting her own firm with higher ideals. She and her pro basketball athlete husband Greg (Blake Griffin) have been married for one year. At home from an injury, Greg commits to renovating the bathroom himself. It does not go well.

As part of her study, Brizendine scans the brains of test subjects. One day, a patient named Kevin Avery (Toby Kebbell) flirts with her before entering the MRI machine. Brizendine is flustered, despite what she’s been telling herself. The scan registers no empathy in his brain, so she dismisses him in her mind. He asks her on a date the next day, and he talks her into it. After, she swiftly initiates sex thinking that this is what he wants, but Kevin turns her down, saying he wants something deeper.

Brizendine moves into a new house and Kevin offers to fix an electrical wire. Again convinced her studies tell her what he wants, she makes it transactional, offering to pay him. Then when Kevin stops by her campus office because she won’t return his texts, Brizendine tells him off and says she is fine without him. He says her testing is flawed because of her bias.

Lexi visits her parents one weekend and realizes her mother fusses over her the same as she has done to Adam. She goes back to Adam’s, who is surprised to see her with no makeup. She apologizes for trying to change him and wants to start over.

Greg is surprised to find a contractor working on the bathroom renovation and they get into a physical fight. Zoe, at home midday, stops the fight and says it was supposed to be a surprise. Then, Zoe states she has quit her job and she wants Greg invest in her new company.

Brizendine herself goes in for a brain scan. Her brain reacts to the stimuli, and she realizes she can’t control it. She admits that female and male brains are different, and that showing emotions is not a sign of weakness, giving a TED talk about it. Realizing she does love Kevin, she finds him at work and says that even if her heart broke, it would be worth it to love him.

Cast

Whitney Cummings as Julia Brizendine

Sofía Vergara as Lisa

Toby Kebbell as Kevin

James Marsden as Adam Simmons

Lucy Punch as Lexi Mercer

Beanie Feldstein as Abby

Cecily Strong as Zoe

Blake Griffin as Greg

Deon Cole as Steven

Marlo Thomas as Lynne Brizendine

Jane Seymour as Cheryl Mercer

Will Sasso as Dennis

Ben Platt as Joel

Adam Shapiro as Hank

Adam Korson as Jimmy

Phil Hendrie as Bill

Neal Brennan as Marco

Alysia Reiner as Erin

Angel Parker as Jennifer

Xosha Roquemore as Maggie

Gwen Hollander as Rebecca

Rebeka Montoya as Lola

Andrew Schulz as Andi

Lisa Linke as Emily

Jaylin Fletcher as Ty

Vinoj Zacharia as Bashir

Rachel LaForce as Lindsay

Beejay Hunter as Zachary

Production

On May 23, 2016, it was announced Whitney Cummings would direct the film, with filming set to begin in July 2016.

Release

The film premiered at the Los Angeles Film Festival on June 17, 2017. In November 2017, IFC Films acquired U.S. distribution rights to the film and set it for a February 9, 2018, release.