Fifth Third Center is a skyscraper located in downtown Cincinnati, Ohio, in the U.S. state of Ohio on Fountain Square. The building has 30 stories and rises to a height of . It is currently the fifth-tallest building in Cincinnati. It was designed by Harrison & Abramovitz and completed in 1969. The building serves as the corporate headquarters for Fifth Third Bank.
On September 6, 2018, the building was the site of a mass shooting, in which four people were killed, including the suspect. Two others were also injured in the shooting.