{ { Drugbox

| IUPAC_name = N,N-Dibutyl-''N-(3-phenyl-1,2,4-oxadiazol-5-yl)ethane-1,2-diamine

| image = butalamine.png

| tradename =

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US =

| legal_status =

| routes_of_administration =

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number = 22131-35-7

| ATC_prefix = C04

| ATC_suffix = AX23

| PubChem = 30949

| DrugBank =

| ChEMBL = 1697825

| ChemSpiderID = 28712

| UNII_Ref =

| UNII = 140T9JTG43

| C=18 | H=28 | N=4 | O=1

| smiles = n1c(onc1c2ccccc2)NCCN(CCCC)CCCC

}}Butalamine is a vasodilator.

Synthesis

Check with imolamine (alternate nitrogen reacts)

Butalamine

The halogenation of benzamidoxime [932-90-1] [622-31-1] (1) with chlorine and subsequent reaction with cyanamide (3) gives 5-amino-3-phenyl-1,2,4-oxadiazole [3663-37-4] (4). Base catalyzed alkylation with dibutylaminoethyl chloride [13422-90-7] (5) completes the synthesis of butalamine (6''').

Butalamine

References

Vasodilators

Oxadiazoles

Butalamine