Lyons became the chief centre of Christian preaching and association in Gaul. As early as the first half of the second century there existed there a Christian congregation, regularly organized as a church, and already sufficiently important to be in intimate and frequent communication with the Christian churches of the East and West. There is a tradition, generally admitted, that St. Pothinus, the first bishop of Lyons, was sent thither from the East by the bishop of Smyrna, St. Polycarp, himself a disciple of St. John. One thing is certain, that the Christian Church of Lyons produced Gaul's first martyrs, among whom was the bishop, St. Pothinus.
It was under Marcus Aurelius, the most philosophical and most conscientious of the emperors, that there was enacted for the first time in Gaul, against nascent Christianity, that scene of tyranny and barbarity which was to be renewed so often and during so many centuries in the midst of Christendom itself. In the eastern provinces of the empire and in Italy the Christians had already been several times persecuted, now with cold-blooded cruelty, now with some slight hesitation and irresolution. Nero had caused them to be burned in the streets of Rome, accusing them of the conflagration himself had kindled, and, a few months before his fall, St. Peter and St. Paul had undergone martyrdom at Rome. Domitian had persecuted and put to death Christians even in his own family, and though invested with the honors of the consulate.
Righteous Trajan, when consulted by Pliny the Younger on the conduct he should adopt in Bithynia toward the Christians, had answered: "It is impossible, in this sort of matter, to establish any certain general rule; there must be no quest set on foot against them, and no unsigned indictment must be accepted; but if they be accused and convicted, they must be punished." To be punished, it sufficed that they were convicted of being Christians; and it was Trajan himself who condemned St. Ignatius, bishop of Antioch, to be brought to Rome and thrown to the beasts, for the simple reason that he was highly Christian. Marcus Aurelius, not only by virtue of his philosophical conscientiousness, but by reason of an incident in his history, seemed bound to be further than any other from persecuting the Christians.